Kentucky: A History of the State, Battle, Perrin, & Kniffin, 2nd ed., 1885, Hancock Co. DR. ISAAC N. GREATHOUSE was born near Bardstown, Ky., about 1792. His father, Harmon Greathouse was born in Pennsylvania. In an early day, he and his two brothers started for Kentucky in a flatboat, and one of his brothers was killed by Indians while making the journey. The second brother settled in Shelby County, and the third brother, Harmon, settled in Nelson County. In an early Indian war he was captured by the Indians. He remained a prisoner some time, but finally escaping settled in Nelson County, Ky., where he resided until his death. Subject was reared in Nelson County and was there educated. He read medicine with Dr. Goodman of that place. In 1818 he went to Troy, Ind., where he practiced his profession. In the latter part of the same year he returned to Kentucky, and married Miss Elizabeth Lewis. This lady was born in Jefferson County, Ky., in 1799. Her parents were John and Hannah Lewis; the father came to Hancock County with his family in 1799, and settled in a fort which then stood on the banks of Yellow Creek. He was a surveyor by occupation, and in an early day made a plat of the major part of the land lying between the Salt and Green Rivers. In 1812, he had listed for taxation over 199,760 acres. This land was, however, considered very cheap; as, speaking about it in a letter written to people in Virginia in 1788, he said that a tract of 2,000 acres on the Ohio River, in what is now Hancock County, could be bought for fifteen farthings, but he remarked that the land in a few months could be bought for ten farthings. Soon after his marriage Isaac Greathouse settled in this county, on the farm owned by his son William. Here he followed his profession and also paid some attention to farming until his death in 1832. His wife was born in 1799 and died in Hancock County in 1879. To her were born seven children, of whom three are now living. H. B., J. L., and William L. Harmon B. Greathouse was born May 2, 1822, in Troy, Ind., and was the second of a family of seven children. His schooling was received in Hancock County. He began life for himself when twenty-three years of age. He first bought a farm near Lewisport, where he resided about two years. From there he farmed for seven years. In 1859 he came to his present farm in Hancock County, where he owns about 173 acres, with about 150 acres in cultivation. Mr. Greathouse was married on February 10, 1840, to Miss Martha R., daughter of James and Catherine (Lewis) Haywood, natives of Henry County. This lady was born in Daviess County, in November, 1827, and was the mother of six children, of whom three are now living: Catherine E., wife of Milton C. Tracy, in Macon, Mo.; Martha H., wife of Thomas L. Henderson, and Isaac N. This lady died September 29, 1862. Mr. G. was next married, December 1, 1868, to Miss Martha E. Haywood, a daughter of George Haywood. This lady was born in Clark County, Mo. (first white female born in that county), in 1830, and to her was born one child, since deceased. She died September, 1878. Subject is a member of the Methodist Episcopal Church South, and has been identified with the Grange fraternity. J. L. Greathouse was born in Hancock County, Ky., March 17, 1828, and was the third of seven children. His education was received in Hancock County. He began life for himself at twenty-five years of age, in Lewisport Precinct. He settled on his present farm in 1864, where he owns 120 acres. In 1864 he erected a saw mill on his farm, and is still running it. Mr. Greathouse was married, January 1, 1855, to Miss S. C. Smith, a daughter of Michael and Sarah (Scott) Smith, natives of Virginia. This lady was born in Henry County, Ky., in 1836. This marriage has resulted in the following children: Nicholas J., Sarah, wife of Stephen Emich; Susan, wife of Rufus Neel; Almenda O., wife of William Roberts; Laura Cooper, Vinson, Clark and Fannie Lou. Mr. Greathouse is a member of the Methodist Episcopal Church South; Mrs. Greathouse of the old school Presbyterian Church. Greathouse Goodman Lewis Haywood Tracy Henderson Smith Scott Emich Neel Roberts = PA Shelby Nelson Jefferson Henry Daviess Clark-MO VA http://www.rootsweb.com/~kygenweb/kybiog/hancock/greathouse.in.txt